Keane, who is manager Martin O'Neill's right-hand man, admits that Germany will be tough to beat on home soil, especially as they suffered a shock 2-0 defeat in Poland on Saturday.
Looking ahead to the Group D clash against last summer's World Cup winners, Keane said: "Obviously, we know the challenge in front of the players.
"But we have got a lot of experience and they have played in big games before. Yes, they should look forward to it and hopefully they will.
"Like any good team, they'll respond to a setback, so we will expect Germany to come out firing on all cylinders and we have to be ready for that."
Regarding Germany's reverse against Poland, Keane added: "It's one defeat for Germany, let's not be getting carried away thinking they are gone.
"They have got top players. Yes, they have lost a few experienced lads, but they always have good young players coming through, whether it be from the under-21s or players who were maybe on the bench during the World Cup.
"Don't think for one minute that Germany are still not a top, top team. They are, of course, they just had one setback.
"From what I hear, they played okay, had decent possession and lost by a couple of goals, which can happen to any team.
"You still expect them to probably be favourites to top the group. The downside from our point of view is you would obviously expect a response from Germany at home, so that makes it maybe even tougher."