New "Grey's Anatomy" season 11 spoilers major relationship changes next season.

First off, it has been reported that the upcoming run will focus on Meredith and Maggie's relationship. As fans can remember, it was revealed in season 10 that Maggie is Meredith's half-sister. The new episodes will apparently deal with the two ladies' awkward feelings for each other.

Season 11 will be heavy on the flashbacks too. As Ellen Pompeo revealed in an interview with E! News, the latest run will even feature flashbacks that happened way before the events in season 1.

"We are doing a lot of flashback stuff. Very challenging....A lot of people say how can you stay on a show 11 years. After 11 seasons you have to stay so alive and present. You can't disappoint the audience. You have to bring it," she said.

Meanwhile, ABC has also revealed the title for the premiere episode to be "I Must Have Lost It On The Wind."

Other "Grey's Anatomy" season 11 spoilers speculate an impending divorce.

As Christian Post reported, "Meredith will move forward although her marriage is on the rocks. Reports claim that Derek and Mer's marriage will be on the verge of divorce. Meredith somehow feels like she has been cast aside and reportedly wants to break up with her husband. However, she will not give up on him easily, but their relationship will eventually end. All signs point to a possibility of divorce although nothing is concrete yet."

"Grey's Anatomy" season 11 premiere on Sept. 25 on ABC.

Stay tuned for more "Grey's Anatomy" season 11 spoilers here!