The 24-year-old, who joined from Ajax in the summer, limped off after a challenge by Eduards Visnakovs in the 20th minute and United will be anxiously awaiting the results of an MRI scan on Monday.

Manager Guus Hiddink gave a grim assessment of the injury when asked about Blind following the final whistle in Amsterdam.

"I'm rather negative," he said. "I think it's a medial ligament that is twisted. It might be a rupture."

Blind himself later posted on his Instagram account: "I'm proud of my 25 games for the Dutch national team, but I'm so gutted with my injury... I'll stay positive (and) will come back stronger! Nevertheless a great win, 6-0!"

Blind has produced some commanding displays in United's midfield and his prolonged absence would be a major blow for manager Louis van Gaal.

The Dutchman had deployed his £14m signing as an emergency central defender following injuries to Phil Jones and Marcos Rojo and the suspension of Chris Smalling.

Van Gaal already had concerns over the fitness of Michael Carrick, who pulled out of the England squad with a groin injury, while goalkeeper David De Gea dislocated his finger in training with Spain.

United have moved up to seventh in the Premier League, despite a stuttering start, but face a tough trip to Arsenal this weekend.